 |
 |
 |
 |
 |
 |
 |
Drosophila and drugsShohat-Ophir G, Kaun KR, Azanchi R, Heberlein U. (2012) Sexual Deprivation Increases Ethanol Intake in Drosophila. Science. [Epub ahead of print] Science Magazine
Kaun KR, Devineni AV, Heberlein U. (2012) Drosophila melanogaster as a model to study drug addiction. Hum Genet. [Epub ahead of print] PubMed Abstract
Kliethermes CL, Heberlein U. (2011) Insulin attenuates the acquisition and expression of ethanol-induced locomotor sensitization in DBA/2J mice. Life Sci. 89(25-26):968-74. PubMed Abstract
King I, Heberlein U. (2011) Tao kinases as coordinators of actin and microtubule dynamics in developing neurons. Commun Integr Biol. 4(5):554-6. Epub 2011 Sep 1.PubMed Abstract
Lasek AW, Gesch J, Giorgetti F, Kharazia V, Heberlein U. (2011) Alk Is a Transcriptional Target of LMO4 and ER{alpha} That Promotes Cocaine Sensitization and Reward. J Neurosci. 31(40):14134-41.PubMed Abstract
Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, Xue L, Robertson M, Moore MS, Vranizan K, Morris SW, Schuckit MA, White RL, Heberlein U. (2011) An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol. PLoS One. 6(7):e22636. PubMed Abstract
Devineni AV, McClure K, Guarnieri D, Corl A, Wolf F, Eddison M, Heberlein U. (2011) The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. Fly (Austin). [Epub ahead of print]. PubMed Abstract
Eddison M, Guarnieri DJ, Cheng L, Liu CH, Moffat KG, Davis G, Heberlein U. (2011) arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. Neuron. 70(5):979-90. PubMed Abstract & Video Abstract
Lasek AW, Giorgetti F, Berger KH, Tayor S, Heberlein U. (2011) Lmo Genes Regulate Behavioral Responses to Ethanol in Drosophila melanogaster and the Mouse. Alcohol Clin Exp Res. [Epub ahead of print]. PubMed Abstract
Kaun KR, Azanchi R, Maung Z, Hirsh J, Heberlein U. (2011) A Drosophila model for alcohol reward. Nat Neurosci. 14(5):612-9. PubMed Abstract
McClure KD, French RL, Heberlein U. (2011) A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. Dis Model Mech. [Epub ahead of print] PubMed Abstract
King I, Tsai LT, Pflanz R, Voigt A, Lee S, Jäckle H, Lu B, Heberlein U. (2011) Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. J Neurosci. 31(3):1139-48. PubMed Abstract
Devineni AV, Heberlein U. (2010) Addiction-like behavior in Drosophila. Commun Integr Biol. 3(4):357-9. PubMed Abstract
Lasek AW, Kapfhamer D, Kharazia V, Gesch J, Giorgetti F, Heberlein U. (2010) Lmo4 in the nucleus accumbens regulates cocaine sensitivity. Genes Brain Behav. 9(7):817-24. PubMed Abstract
Kapfhamer D, Berger KH, Hopf FW, Seif T, Kharazia V, Bonci A, Heberlein U. (2010) Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. J Neurosci. 30;30(26):8830-40. PubMed Abstract
Kong EC, Woo K, Li H, Lebestky T, Mayer N, Sniffen MR, Heberlein U, Bainton RJ, Hirsh J, Wolf FW. (2010) A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila. PLoS One. 1;5(4):e9954. PubMed Abstract
Devineni AV, Heberlein U. (2009) Preferential Ethanol Consumption in Drosophila Models Features of Addiction. Curr Biol. 19(24):2126-32. PubMed Abstract
Kong EC, Allouche L, Chapot PA, Vranizan K, Moore MS, Heberlein U, Wolf FW. (2009) Ethanol-Regulated Genes That Contribute to Ethanol Sensitivity and Rapid Tolerance in Drosophila. Alcohol Clin Exp Res. 34(2):302-16. PubMed Abstract
French RL, Heberlein U (2009) Glycogen synthase kinase-3/Shaggy mediates ethanol-induced excitotoxic cell death of Drosophila olfactory neurons. Proc Natl Acad Sci USA. 106(49):20924-9. PubMed Abstract
Kaun KR, Heberlein U. (2009) Too fat to fly? New brain circuits regulate obesity in Drosophila. Neuron. 13;63(3):279-81. PubMed Abstract
Joseph RM, Devineni AV, King IF, Heberlein U (2009) Oviposition preference for and positional avoidance of acetic acid provide a model for competing behavioral drives in Drosophila. Proc Natl Acad Sci USA. 106(27):11352-7. PubMed Abstract
Corl AB, Berger KH, Ophir-Shohat G, Gesch J, Simms JA, Bartlett SE, Heberlein U (2009) Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell. 137(5):802-4. PubMed Abstract
Häsemeyer M, Yapici N, Heberlein U, Dickson BJ. (2009) Sensory neurons in the Drosophila genital tract regulate female reproductive behavior. Neuron. 61(4):511-8.PubMed Abstract
Heberlein U, Tsai LT, Kapfhamer D, Lasek AW. (2009) Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins. Neuropharmacology. 56 Suppl 1:97-106. PubMed Abstract
Berger KH, Kong EC, Dubnau J, Tully T, Moore MS, Heberlein U (2008) Ethanol sensitivity and tolerance in long-term memory mutants of Drosophila. Alcohol Clin Exp Res. 32(5):895-908. PubMed Abstract
LaFerriere H, Guarnieri DJ, Sitaraman D, Diegelmann S, Heberlein U, Zars T. (2008) Genetic dissociation of ethanol sensitivity and memory formation in Drosophila. Genetics. 178(4):1895-902. PubMed Abstract
Kapfhamer D, Bettinger JC, Davies AG, Eastman CL, Smail EA, Heberlein U, McIntire SL. (2008) Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Genes Brain Behav. 7(6):669-76. PubMed Abstract
Lasek AW, Janak PH, He L, Whistler JL, Heberlein U. Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. (2007) Genes Brain Behav.6(8):728-35. PubMed Abstract
Wolf FW, Eddison M, Lee S, Cho W, Heberlein U (2007) GSK-3/Shaggy regulates olfactory habituation in Drosophila. Proc Natl Acad Sci USA 104(11):4653-7. PubMed Abstract
Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U (2006) Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell 127(1):199-211. PubMed Abstract
Janak PH, Wolf FW, Heberlein U, Pandey SC, Logrip ML, Ron D (2006) BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF. Alcohol Clin Exp Res 30:214-21. PubMed Abstract
Bainton RJ, Tsai, LTY, Schwabe T, DeSalvo M, Gaul U, Heberlein U (2005) moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell 123:145-156. PubMed Abstract
Scholz H, Franz M, Heberlein U (2005) The hangover gene defines a stress pathway required for ethanol tolerance development. Nature 436:845-7. PubMed Abstract
Corl AB, Rodan AR, Heberlein U (2005) Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci 8:18-19. PubMed Abstract
Berger KH, Heberlein U, Moore MS (2004) Rapid and chronic: two distinct forms of ethanol tolerance in Drosophila. Alcohol Clin Exp Res 10:1469-80. PubMed Abstract
Tsai LT, Bainton RJ, Blau J, Heberlein U (2004) Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol 12:E408. PubMed Abstract | PDF Article (495 MB)
Cho W, Heberlein U, Wolf FW (2004) Habituation of an odorant-induced startle response in Drosophila. Genes Brain Behav 3:127-37. PubMed Abstract
Guarnieri DJ, Heberlein U (2003) Drosophila melanogaster, a genetic model system for alcohol research. Int Rev Neurobiol 54:199-228. PubMed Abstract
Rothenfluh A, Heberlein U. Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion (2003) Curr Opin Neurobiol 6:639-45. PubMed AbstractWolf FW, Heberlein U (2003) Invertebrate models of drug abuse. J Neurobiol 54:161-78. Review. PubMed Abstract
Wolf FW, Rodan AR, Tsai LT, Heberlein U (2002) High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci 22:11035-44. PubMed AbstractRodan AR, Kiger JA Jr, Heberlein U (2002) Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J Neurosci 22:9490-501. PubMed Abstract
Cheng Y, Endo K, Wu K, Rodan AR, Heberlein U, Davis RL (2001) Drosophila fasciclin II is required for the formation of odor memories and for normal sensitivity to alcohol. Cell 105:757-68. PubMed Abstract
Heberlein U (2000) Genetics of alcohol-induced behaviors in Drosophila. Alcohol Res Health 24:185-8. PubMed Abstract
Scholz H, Ramond J, Singh CM, Heberlein U (2000) Functional ethanol tolerance in Drosophila. Neuron 28:261-71. PubMed Abstract
Singh CM, Heberlein U (2000) Genetic control of acute ethanol-induced behaviors in Drosophila. Alcohol Clin Exp Res 24:1127-36. PubMed Abstract
Bainton RJ, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein U (2000) Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol 10:187-94. PubMed AbstractTecott LH, Heberlein U (1998) Y do we drink? Cell 95:733-5. No abstract available
Moore MS, DeZazzo J, Luk AY, Tully T, Singh CM, Heberlein U (1998) Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93:997-1007. PubMed AbstractDrosophila eye development
Chanut F, Woo K, Pereira S, Donohoe TJ, Chang SY, Laverty TR, Jarman AP, Heberlein U (2002) Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation. Genetics 160:623-35. PubMed AbstractChanut F, Luk A, Heberlein U (2000) A screen for dominant modifiers of ro(Dom), a mutation that disrupts morphogenetic furrow progression in Drosophila, identifies groucho and hairless as regulators of atonal expression. Genetics 156:1203-17. PubMed Abstract
Heberlein U, Treisman JE (2000) Early retinal development in Drosophila. Results Probl Cell Differ 31:37-50. No abstract available
Borod ER, Heberlein U (1998) Mutual regulation of decapentaplegic and hedgehog during the initiation of differentiation in the Drosophila retina. Dev Biol 197:187-97. PubMed AbstractHeberlein U, Borod ER, Chanut FA (1998) Dorsoventral patterning in the Drosophila retina by wingless. Development 125:567-77. PubMed Abstract
Treisman JE, Heberlein U (1998) Eye development in Drosophila: formation of the eye field and control of differentiation. Curr Top Dev Biol 39:119-58. No abstract availableTreisman JE, Luk A, Rubin GM, Heberlein U (1997) eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins. Genes Dev 11:1949-62. PubMed Abstract
Chanut F, Heberlein U (1997) Retinal morphogenesis in Drosophila: hints from an eye-specific decapentaplegic allele. Dev Genet 20:197-207. PubMed Abstract
Chanut F, Heberlein U (1997) Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina. Development 124:559-67. PubMed Abstract
Chanut F, Heberlein U (1995) Role of the morphogenetic furrow in establishing polarity in the Drosophila eye. Development 121:4085-94. PubMed Abstract
Heberlein U, Moses K (1995) Mechanisms of Drosophila retinal morphogenesis: the virtues of being progressive. Cell 81:987-90. No abstract available
Heberlein U, Singh CM, Luk AY, Donohoe TJ (1995) Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 373:709-11. PubMed Abstract
Heberlein U, Penton A, Falsafi S, Hackett D, Rubin GM (1994) The C-terminus of the homeodomain is required for functional specificity of the Drosophila rough gene. Mech Dev 48:35-49. PubMed Abstract
Heberlein U, Wolff T, Rubin GM. (1993) The TGF beta homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. Cell. 75:913-26. PubMed Abstract
Heberlein U, Hariharan IK, Rubin GM (1993) Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1. Dev Biol. 160:51-63. PubMed Abstract
Heberlein U, Mlodzik M, Rubin GM (1991) Cell-fate determination in the developing Drosophila eye: role of the rough gene. Development 112:703-12. PubMed AbstractHeberlein U, Rubin GM (1991) Star is required in a subset of photoreceptor cells in the developing Drosophila retina and displays dosage sensitive interactions with rough. Dev Biol 144:353-61. PubMed Abstract
Heberlein U, Rubin GM (1990) Structural and functional comparisons of the Drosophila virilis and Drosophila melanogaster rough genes. Proc Natl Acad Sci U S A 87:5916-20. PubMed Abstract
Kimmel BE, Heberlein U, Rubin GM (1990) The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev 4:712-27. PubMed Abstract
Alcohol dehydrogenase & other early work
England BP, Heberlein U, Tjian R (1990) Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1), binds to sites in several Drosophila promoters and activates transcription. J Biol Chem 265:5086-94. PubMed Abstract
Moses K, Heberlein U, Ashburner M (1990) The Adh gene promoters of Drosophila melanogaster and Drosophila orena are functionally conserved and share features of sequence structure and nuclease-protected sites. Mol Cell Biol 10:539-48. PubMed Abstract
Heberlein U, Tjian R (1988) Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts. Nature 331:410-5. PubMed Abstract
Bray SJ, Johnson WA, Hirsh J, Heberlein U, Tjian R (1988) A cis-acting element and associated binding factor required for CNS expression of the Drosophila melanogaster dopa decarboxylase gene. EMBO J 7:177-88. PubMed AbstractHeberlein U, England B, Tjian R (1985) Characterization of Drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene. Cell 41:965-77. PubMed Abstract
Brake AJ, Merryweather JP, Coit DG, Heberlein UA, Masiarz FR, Mullenbach GT, Urdea MS, Valenzuela P, Barr PJ (1984) Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 81:4642-6. PubMed AbstractUrdea MS, Merryweather JP, Mullenbach GT, Coit D, Heberlein U, Valenzuela P, Barr PJ (1983) Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast. Proc Natl Acad Sci U S A 80:7461-5. PubMed Abstract